Lung Disease Clinical Trials

A listing of Lung Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 680 clinical trials
First-in-Human Dose Escalation Trial of ATRC-101 in Adults With Advanced Solid Malignancies

ATRC-101-A01 is a first-in-human, Phase 1b, open-label trial to characterize the safety, tolerability, pharmacokinetics (PK), and biological activity of escalating doses of ATRC-101, an engineered, fully human immunoglobulin G, subclass 1 (IgG1) antibody derived from a naturally-occurring human antibody.

cancer of the ovary
breast cancer
measurable disease
growth factor
colorectal cancer
  • 0 views
  • 19 Feb, 2024
  • 1 location
Brief Title: Study of BGB-10188 as Monotherapy and in Combination With Zanubrutinib and Tislelizumab

The purpose of this study is to determine the maximum tolerated dose (MTD), recommended Phase 2 dose(RP2D),safety & tolerability of BGB-10188: as monotherapy in participants with mature B-cell malignancies; oin combination with zanubrutinib in participants with relapse/refractory follicular lymphoma (R/R FL), mantle cell lymphoma (MCL) or diffuse large B-cell lymphoma …

endometrial carcinoma
diffuse large b-cell lymphoma
breast cancer
cancer of the ovary
solid tumor
  • 0 views
  • 19 Feb, 2024
  • 4 locations
A Study of SGN-B6A in Advanced Solid Tumors

This trial will look at a drug called SGN-B6A to find out whether it is safe for people who have solid tumors. It will study SGN-B6A to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether …

solid tumour
cancer of the ovary
breast cancer
gastric cancer
pancreatic adenocarcinoma
  • 0 views
  • 19 Feb, 2024
  • 3 locations
Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death

Normothermic regional perfusion (NRP) utilizes Extracorporeal Membrane Oxygenation (ECMO) or cardiopulmonary bypass to reperfuse the heart and other organs in situ after isolation and ligation of the cerebral vessels. In situ resuscitation of the heart has the added advantage of allowing full hemodynamic and echocardiographic assessment of the donor heart …

heart transplantation
  • 0 views
  • 19 Feb, 2024
  • 1 location
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work in treating patients with pneumonitis that does not respond to steroid treatment. Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow …

corticosteroid therapy
monoclonal antibodies
solid tumor
steroid treatment
infliximab
  • 0 views
  • 19 Feb, 2024
  • 1 location
Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI

Rationale: Transcatheter aortic valve implantation (TAVI) has become the standard therapy for elderly patients with high surgical risks. Paravalvular leakage after TAVI is relatively common and there is conflicting evidence regarding the clinical impact of mild paravalvular leakage in self-expanding devices. Prospective data for self-expanding devices are required to compare …

cardiac mri
coronary artery disease
stroke
dialysis
aortic valve stenosis
  • 0 views
  • 19 Feb, 2024
  • 1 location
External Dead Space in Ventilated COVID-19 Patients

The objective is to investigate the efficacy of volumetric capnography to detect changes in dead space, CO2 elimination and shape factor parameters before and after disconnection of external dead space in ventilated COVID-19 patients.

mechanical ventilation
covid-19
  • 0 views
  • 19 Feb, 2024
  • 1 location
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow …

tubal ligation
meningiomatosis
karnofsky performance status
bilateral tubal ligation
glioma
  • 0 views
  • 19 Feb, 2024
  • 2 locations
Training Single Arm

The pulmonary hypertension is a disease, which tends to a progredient right heart failure. Although there was a large progress in development of medical therapy, the quality of life, the physical efficiency and the prognosis of the patients are still limited. The aim of the study is to examine the …

right heart catheterization
right ventricular failure
medical therapy
heart failure
hypertension
  • 0 views
  • 19 Feb, 2024
  • 1 location
Concurrent Chemoradiation and Durvalumab for Locoregionally Advanced Nasopharyngeal Carcinoma

The investigators propose a phase II randomized-controlled study on using durvalumab in combination with induction chemotherapy followed by concurrent chemoradiation and adjuvant durvalumab, compared to induction chemotherapy followed by concurrent chemoradiation for previously untreated locoregionally advanced stage III to IVA NPC. In parallel, the investigators will also perform collateral tumor …

irreversible toxicity
adjuvant
immunomodulators
topical steroids
pd-l1
  • 0 views
  • 19 Feb, 2024
  • 1 location