Incidence of Diabetes and Metabolic Disorders After TIPS in Cirrhotic Patients

  • STATUS
    Recruiting
  • participants needed
    111
  • sponsor
    University Hospital, Toulouse
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Updated on 19 February 2024
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Summary

Decompensated cirrhosis is associated with sarcopenia. TIPS is an efficient treatment of portal hypertension. Based on our retrospective data, TIPS induces in 30% of cirrhotic patients metabolic disorders associated with diabetes or pre-diabetes. The main objective is to measure the cumulative incidence of diabetes and pre-diabetes 6 months after TIPS insertion.

Description

Based on our retrospective data, we expect that one-third of cirrhotic patients develop glucose dysregulation after TIPS. A better knowledge of the metabolic disorders related to the TIPS could allow to prevent the deleterious effects of the TIPS on the disease (decrease of the insulin-sensitivity, fat gain ...), by simple interventions on diet or physical activity. We will assess the incidence of diabetes and pre-diabetes, and the influence of TIPS on nutritional status and sarcopenia. Patients will be follow-up 6 months after TIPS. We will explore the hormonal mechanisms that explain these changes.

Details
Condition Cirrhosis Portal
Age 18years - 70years
Treatment TIPS
Clinical Study IdentifierNCT04387058
SponsorUniversity Hospital, Toulouse
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

patient cirrhosis and portal hypertension justifying a treatment with TIPS
written consent

Exclusion Criteria

contraindication for TIPS
indications of TIPS in emergency or as part of the preparation for a surgical procedure
hepatocellular carcinoma outside Milan criteria or cancer at a palliative stage
a contra-indication to the realization of an OGTT
a hyperglycemic treatment (corticosteroids, somatostatin, etc.)
hemoglobin <7 g / dl
patients who have had a liver transplant
those for whom the follow-up is considered impossible or the vital prognosis is engaged in the short term
pregnant or lactating women
those unable to receive enlightened information
those participating in interventional research
and finally the persons placed under safeguard of justice, tutelage or curatorship
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Investigator Avatar
Maeva GUILLAUME

Primary Contact

CHU de Toulouse

France

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