Incidence of Diabetes and Metabolic Disorders After TIPS in Cirrhotic Patients
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- STATUS
- Recruiting
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- participants needed
- 111
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- sponsor
- University Hospital, Toulouse
Summary
Decompensated cirrhosis is associated with sarcopenia. TIPS is an efficient treatment of portal hypertension. Based on our retrospective data, TIPS induces in 30% of cirrhotic patients metabolic disorders associated with diabetes or pre-diabetes. The main objective is to measure the cumulative incidence of diabetes and pre-diabetes 6 months after TIPS insertion.
Description
Based on our retrospective data, we expect that one-third of cirrhotic patients develop glucose dysregulation after TIPS. A better knowledge of the metabolic disorders related to the TIPS could allow to prevent the deleterious effects of the TIPS on the disease (decrease of the insulin-sensitivity, fat gain ...), by simple interventions on diet or physical activity. We will assess the incidence of diabetes and pre-diabetes, and the influence of TIPS on nutritional status and sarcopenia. Patients will be follow-up 6 months after TIPS. We will explore the hormonal mechanisms that explain these changes.
Details
| Condition | Cirrhosis Portal |
|---|---|
| Age | 18years - 70years |
| Treatment | TIPS |
| Clinical Study Identifier | NCT04387058 |
| Sponsor | University Hospital, Toulouse |
| Last Modified on | 19 February 2024 |
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