Non Exudative AMD Imaged With SS-OCT- Extension

STATUS

Recruiting
participants needed

450
sponsor

Boston Image Reading Center

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Updated on 19 February 2024

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age-related macular degeneration

retinal pigment

drug trials

macular degeneration

maculopathy

Summary

The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.

Description

Details

Condition	Dry Macular Degeneration, age-related macular degeneration, macular degeneration, macular degeneration
Age	100years or below
Treatment	SS-OCT imaging
Clinical Study Identifier	NCT04469140
Sponsor	Boston Image Reading Center
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Enrollment in and completion of the BIRC-01 study
	Clinic diagnosis of non-exudative iAMD in at least one eye with a drusen volume in the central 3 mm circle centered on the fovea of at least 0.02 mm3 in the absence of GA or nGA as diagnosed with OCT en face imaging OR Clinical diagnosis of early or early/intermediate stage AMD in one eye in the absence of nGA or GA and exudative AMD in the other eye OR clinical diagnosis of GA or nGA secondary to AMD that is at least the size of a large druse (125 microns in diameter; 0.05 mm2) and no greater than 7 disc areas (17 mm2) in at least one eye which has never been treated with anti-VEGF agents
	Willing and able to comply with clinic visits and study-related procedures
	Provide signed informed consent
Exclusion Criteria
	Subjects with exudative AMD in both eyes
	Eyes with evidence of non-proliferative and proliferative diabetic retinopathy
	Presence of confounding ocular diagnosis such as myopia >6D, or other ocular conditions that may cause retinal pigment epithelium atrophy or exudative MNV
	Subjects currently or previously enrolled in other interventional clinical trials in which treatment was administered to the study eye
	Previous vitrectomy or intravitreal injections in the study eye
	Axial length measurement 26 mm
	Subjects unable to give informed consent
	Subjects who are unable to comply with imaging guidelines

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Study Definition

Wikipedia

Non Exudative AMD Imaged With SS-OCT- Extension