Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI
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- STATUS
- Recruiting
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- End date
- May 1, 2026
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- participants needed
- 20
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- sponsor
- Jonsson Comprehensive Cancer Center
Summary
This trial looks to study the safety and feasibility of using oxygen-enhanced molecular MRI to understand how cancer cells use oxygen differently than normal cells. Cancer cells tend to utilize (or not utilize) oxygen differently than normal cells. By using the oxygen-enhanced molecular MRI, researchers will be able to create spatial "maps" depicting areas of abnormal oxygen utilization unique to cancer. This type of information may be useful for diagnosing new cancers, understanding various "subtypes" of cancer that might utilize oxygen differently, or this information may be useful for evaluating new drugs that impact cancer metabolism.
Description
PRIMARY OBJECTIVES:
I. Determine the safety, feasibility, and sensitivity of oxygen-enhanced molecular magnetic resonance imaging (MRI) in healthy volunteers.
II. Measure oxygen-enhanced molecular MRI characteristics in human brain tumors.
- OUTLINE
Participants undergo arterial spin labeling (ASL) MRI scan and amine chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging using amine proton CEST echo spin-and-gradient echo (SAGE) EPI (CEST-SAGE-EPI) while breathing normal room air (21% oxygen). Patients then undergo another ASL MRI and CEST-SAGE-EPI while breathing medical grade air (100% oxygen). Total ASL MRI and CEST-SAGE-EPI imaging scan time is 60 minutes.
Details
| Condition | Malignant neoplasm of brain |
|---|---|
| Age | 100 years and younger |
| Treatment | Arterial Spin Labeling Magnetic Resonance Imaging, pH-Weighted amine CEST, Oxygen-weighted SAGE-EPI |
| Clinical Study Identifier | NCT04460495 |
| Sponsor | Jonsson Comprehensive Cancer Center |
| Last Modified on | 19 February 2024 |
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