Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection

  • STATUS
    Recruiting
  • participants needed
    90
  • sponsor
    Cambridge University Hospitals NHS Foundation Trust
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Updated on 19 February 2024
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covid-19
SARS
acute respiratory syndrome (sars)

Summary

This study is designed to investigate the acuity of olfactory dysfunction in COVID-19 positive patients in the United Kingdom. In particular defining severity with objective testing and determining if this has any predictive value on the outcome of the SARS CoV-2 infection. In addition, this study will strive to determine duration / natural history of olfactory dysfunction in these patients in respect to a positive SARS CoV-2 diagnosis. It should also demonstrate the impact of olfactory dysfunction on patient Quality of Life (QOL).

Description

The main objective of this study is to evaluate olfactory acuity by means of a multidimensional assessment protocol to objectively demonstrate the severity of olfactory dysfunction in patients diagnosed with SARS CoV-2. The University of Pennsylvania Smell Identification Test (UPSIT) will be used to assess olfactory function in newly diagnosed patients and also existing patients longitudinally over a 12-month period. This is to document onset (where possible) and rate of progress of olfactory dysfunction.

In relevant cases, the investigators will correlate their findings with severity of the Acute Respiratory Distress Syndrome (ARDS) arising as a result of the infection - characterised as mild, moderate and severe according to the Berlin classification. The investigators will therefore determine if the degree of olfactory dysfunction correlates in any manner to the severity of ARDS developed in a positive SARS CoV-2 patient and if it offers any prognosticative applications.

The investigators will also examine the impact of the symptom of olfactory dysfunction on patient Quality of Life using two validated tools known as the Questionnaire of Olfactory Disorders for English speakers (eQOD) and the SNOT-22 questionnaire.

Furthermore, outcomes will be explored and stratified in terms of age, gender and ethnicity

Details
Condition Intrauterine Growth Retardation, Anosmia, Quality of life, COVID19, Olfactory Disorder, SARS-CoV-2
Age 18years - 85years
Clinical Study IdentifierNCT04466982
SponsorCambridge University Hospitals NHS Foundation Trust
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients who are presenting to hospital with symptoms of SARS CoV-2 infection
Patients who go on to develop a positive SARS CoV-2 test
Patients who can give a valid written informed consent
Patients who are motivated to participate in the study
Adult patients aged 18 years - 85 years

Exclusion Criteria

Patients who cannot give a valid written informed consent
Patients who are not willing or not motivated to participate in the study
Patients with negative SARS CoV-2 tests
Patients with nasal pathologies like severe deviated nasal septum, nasal masses, head trauma or previously known chronic rhinosinusitis with polyps or on medication for more than 6 months/year for at least one year for chronic rhinosinusitis
Patients with any diagnosed neurological disease known to affect olfactory function will be excluded from the study
Patients unable to read in the English language
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