Determination of Diastolic Dysfunction by Single Lead Electrocardiogram
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- STATUS
- Recruiting
-
- participants needed
- 400
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- sponsor
- I.M. Sechenov First Moscow State Medical University
Summary
It is a prospective, controlled, single-center, non-randomized, observational study.
From September 2019 to December 2020, the study plans to prospectively include 400 patients aged 18 to 90 years.
Every patients will undergo an echocardiographic examination with assessment diastolic
dysfunction of the left ventricle, and registration of an
The result of this study will be the identification of ECG parameters that will correlate
with LV
Description
It is a prospective, controlled, single-center, non-randomized, observational study.
From September 2019 to December 2020, the study plans to prospectively include 400 patients aged 18 to 90 years.
The goal of study is reveal single parameters of the
Investigators plan to assess the diagnostic effectiveness of the spectral analysis of
All subjects will undergo an echocardiographic examination of the heart with a determination
of
At the same time, for all patients single-lead ECG will be recorded (in turn of leads I) for 3 minutes with further spectral analysis of the data obtained.
A single-lead
Then a spectral analysis of the
The analysis implies an assessment of the following parameters (the parameters listed below will be calculated as the median of the tact-cycle):
- TpTe - time from peak to end of the T-wave
- VAT - time from the beginning of the QRS to the R-peak
- QTc - corrected QT interval.
- QT / TQ - the ratio of QT length to TQ length (from the end of T to the beginning of the QRS of the next complex).
- QRS_E - the total energy of the QRS wave based on the wavelet transform
- T_E - T-wave total energy based on wavelet transform
- TP_E- energy of the main tooth of the T-wave based on the wavelet transform
- BETA, BETA_S - T-wave asymmetry coefficients (simple and smooth versions)
- BAD_T - flag of T-wave quality (whether expressed in the current lead
- QRS_D1_ons - energy of the leading edge of the R-wave (based on the "first derivative" wavelet transform)
- QRS_D1_offs - energy of the trailing edge of the R-wave (based on the "first derivative" wavelet transform)
- QRS_D2 - peak energy of the R-wave (based on the "second derivative" wavelet transform)
- QRS_Ei (i = 1,2,3,4) - QRS-wave energy in 4 frequency ranges (2-4-8-16-32 Hz) based on wavelet transform
- T_Ei (i = 1,2,3,4) - T-wave energy in 4 frequency ranges (2-4-6-8-10 Hz) based on wavelet transform
- HFQRS - the amplitude of the RF components of the QRS wave
Additionally used parameters:
- TpTe, VAT, QTc - are duplicated to control the correctness of the record processing (the value of the UCC should be approximately equal to the median of the tick-by-bar).
- QRSw - QRS width.
- RA, SA, TA - the amplitudes of the R, S, T-waves, respectively, are used to normalize the parameters listed above.
Statistical processing of results: SPSS Statistics Version 26 is a computer program for statistical processing of data.
The result of this study will be the identification of ECG parameters that will correlate
with LV
Investigators also plan to analyze ECG parameters characteristic of patients with LV
- patients suffering from
high blood pressure with patients without the above pathology - patients with zones of a- and hypokinesis according to
echocardiography as a result of a coronarycirculation disorder - patients suffering from
atrial fibrillation with patients without this pathology - men / women
- patients of different age groups
During statistical processing of the data, the following will be calculated:
Details
Condition | Diastolic Function |
---|---|
Age | 18years - 90years |
Treatment | echocardiographic examination |
Clinical Study Identifier | NCT04474639 |
Sponsor | I.M. Sechenov First Moscow State Medical University |
Last Modified on | 19 February 2024 |
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