Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer
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- STATUS
- Recruiting
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- End date
- Aug 1, 2027
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- participants needed
- 60
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- sponsor
- University of Washington
Summary
This phase II study investigates how well radium-223 works in treating patients with castration-resistant prostate cancer than has spread to the bones (bone metastases). Prostate cancer is the most common cancer in men and the second leading cause of cancer death. Furthermore, many men with notably advanced disease have been found to have abnormalities in DNA repair. The purpose of this research is to study the role of a DNA repair pathway in prostate cancer, specifically in response to administration of radium-223, an FDA-approved drug known to cause DNA damage to cancerous cells. Understanding how defects in the DNA repair pathway affects radium-223 treatment of prostate, may help doctors help plan effective treatment in future patients.
Description
- OUTLINE
Patients receive standard of care radium Ra 223 dichloride given by intravenous (IV) bolus every 4 weeks for up to 6 cycles. Patients undergo collection of blood every 1-3 months during radium Ra 223 dichloride treatment.
After completion of study, patients are followed up every 3 months for up to 5 years from the date of treatment completion.
Details
| Condition | Metastatic Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone |
|---|---|
| Age | 18-100 years |
| Treatment | Questionnaire Administration, Biospecimen Collection, Radium Ra 223 Dichloride |
| Clinical Study Identifier | NCT04489719 |
| Sponsor | University of Washington |
| Last Modified on | 19 February 2024 |
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