Pyrotinib Trastuzumab Pertuzumab and Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer
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- STATUS
- Recruiting
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- End date
- Dec 30, 2027
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- participants needed
- 216
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- sponsor
- Shanghai Jiao Tong University School of Medicine
Summary
This study aims to evaluate the efficacy and safety of pyrotinib in combination with trastuzumab, pertuzumab and nab-paclitaxel as neoadjuvant therapy in early stage or locally advanced HER2-positive breast cancer.
Description
The study evaluate the pathological complete response rate, event-free survival, disease-free survival, overall survival and safety of pyrotinib in combination with trastuzumab, pertuzumab and nab-paclitaxel as neoadjuvant therapy in early stage or locally advanced HER2-positive breast cancer. Patients will receive 4 cycles of pyrotinib in combination with trastuzumab, pertuzumab and nab-paclitaxel or 4 cycles of trastuzumab, pertuzumab and nab-paclitaxel as neoadjuvant therapy, then undergo surgery, then receive adjuvant chemotherapy and targeted therapy according to pathologic response and physician's choice.
Details
| Condition | Breast Cancer Invasive |
|---|---|
| Age | 18-75 years |
| Treatment | Surgery, nab-paclitaxel, Trastuzumab, Pyrotinib, Pertuzumab, EC chemotherapy, Physician's choice, T-DM1 |
| Clinical Study Identifier | NCT04398914 |
| Sponsor | Shanghai Jiao Tong University School of Medicine |
| Last Modified on | 19 February 2024 |
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