Open-label Study to Determine the Maximum Tolerated Dose of DSG3-CAART in Mucosal-dominant PV Patients (mPV)
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- STATUS
- Recruiting
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- End date
- Aug 5, 2026
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- participants needed
- 30
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- sponsor
- Cabaletta Bio
Summary
Mucosal-dominant pemphigus vulgaris (mPV) is a B-cell mediated autoimmune disorder in which painful blisters are formed on the mucosal membrane, including the mouth, nose, throat, eyelids, anus, and genitals. This phase 1 study is being conducted to find the maximum tolerated dose and optimal fractionated infusion schedule of an investigational cell therapy, DSG3-CAART, that can be given to patients with mPV who are inadequately managed by standard therapies. DSG3-CAART may potentially lead to complete and durable remission of disease.
Details
| Condition | Mucosal -Dominant Pemphigus Vulgaris |
|---|---|
| Age | 18-100 years |
| Treatment | DSG3-CAART |
| Clinical Study Identifier | NCT04422912 |
| Sponsor | Cabaletta Bio |
| Last Modified on | 19 February 2024 |
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