Dual-scopic Pancreatic Necrosectomy (DPN)

STATUS

Recruiting
End date

Dec 31, 2025
participants needed

20
sponsor

First People's Hospital of Hangzhou

Send

Updated on 19 February 2024

See if I qualify

ct scan

cavity

abdominal pain

cavities

lipase

serum amylase

abdominal ct scan

cholecystectomy

colic

necrosectomy

stomach pain

normal saline

seldinger technique

Summary

The LPN procedure is performed under general anesthesia. The transperitoneal access to peripancreatic space is via the gastro-colic ligament and greater omentum, effusion and pus is removed by laparoscopic forceps and suction. Laparoscopic cholecystectomy (LC) is performed during the LPN procedure on patients with indication.

The NPN procedure is followed by the standard retroperitoneal approach. After the catheter is exchanged over a guide wire and serially dilated up from 6F to 24F followed by Seldinger technique, the access track to the necrotic cavity is established. A nephroscope is inserted into the cavity through the track for debridement. Using forceps and suction, the peripancreatic solid necrotic tissue and pus is grasped and removed. A large-bore irrigating drain is left in the cavity, with continuous irrigation by warm normal saline solution at a rate of 100-125 ml/h after surgery.

Details

Condition	Pancreatitis, Pancreatitis, Pancreatic disorder, Necrotizing pancreatitis
Age	18years - 100years
Treatment	Dual-scopic pancreatic necrosectomy（DPN）
Clinical Study Identifier	NCT04443595
Sponsor	First People's Hospital of Hangzhou
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	All patients ages 18 or above admitted to UPMC with a diagnosis of AP based on at least 2 of the following criteria:(i) abdominal pain characteristic of AP (ii) serum amylase and/or lipase 3 times the upper limit of normal (iii) characteristic findings of AP on abdominal CT scan will be screened for study enrollment
Exclusion Criteria
	Less than 18 years of age
	Pregnant women
	Presence of renal dysfunction (Cr>1.5mg/dL)
	Pre existing heart dysfunction or NYHA classification score above III
	Coagulation disorder

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Study Definition

Wikipedia

Dual-scopic Pancreatic Necrosectomy (DPN)