Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

  • STATUS
    Recruiting
  • participants needed
    58
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 19 February 2024
clindamycin
malignant glioma
glioblastoma multiforme
topical agents
triamcinolone
tumor treating fields therapy
glioma
ttfields
triamcinolone topical

Summary

The participants are being treated with Tumor Treating Fields (TTFields) for malignant glioma, and this type of treatment may cause skin-related side effects. This study will test whether using clindamycin and triamcinolone topical lotions can prevent skin-related side effects of TTFields.

Details
Condition Glioblastoma Multiforme, Glioblastoma Multiforme, Skin Toxicity
Age 18years - 100years
Treatment Triamcinolone Acetonide, Clindamycin Phosphate
Clinical Study IdentifierNCT04469075
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years
Diagnosis of newly diagnosed GBM or any malignant glioma with plan to initiate treatment with TTFields with or without systemic therapy, confirmed by the enrolling institution
Able to self-administer topical interventions or has available another person who can apply the topical agents
Treatment with TTF should be initiated within 7 days of planned initiation on this trial

Exclusion Criteria

Known history of allergy to any ingredient of the study agents
Preexisting scalp disorders such as psoriasis or dermatitis that, in the opinion of the investigator, will affect the grading of skin adverse events, confirmed by enrolling institution
Use of concurrent topical therapy to the scalp for another dermatologic condition
Active, uncontrolled infection requiring systemic or oral antibiotic therapy within 14 days of enrollment
Use of dexamethasone 2mg a day or greater within 14 days of enrollment
Recurrent GBM or malignant glioma
Concurrent administration of bevacizumab
Clear my responses

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