Nedaplatin Versus Cisplatin in Treatment for Nasopharyngeal Carcinoma
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- STATUS
- Recruiting
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- End date
- Jun 30, 2029
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- participants needed
- 352
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- sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Summary
To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.
Description
This is a prospective, parallel, randomized, open labeled, phase III, non-inferiority clinical trial to compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma patients in endemic area - nedaplatin, docetaxel and fluorouracil as induction chemotherapy regimen combined with nedaplatin as concurrent chemoradiotherapy (DNF-N) versus cisplatin, docetaxel and fluorouracil as induction chemotherapy regimen combined with cisplatin as concurrent chemoradiotherapy (DPF-P). All patients will receive radical intense modulate radiation therapy (IMRT). The primary endpoint is progress free survival (PFS).
Details
| Condition | Carcinoma, vulvar dysplasia and carcinoma, Nasopharyngeal Cancer, Nasopharyngeal Cancer, vulvar dysplasia and carcinoma |
|---|---|
| Age | 18years - 65years |
| Treatment | Cisplatin, Docetaxel, nedaplatin, fluorouracil, Docetaxel, cisplatin, fluorouracil, Nedaplatin, Intensity modulated-radiotherapy |
| Clinical Study Identifier | NCT04437329 |
| Sponsor | Affiliated Cancer Hospital & Institute of Guangzhou Medical University |
| Last Modified on | 19 February 2024 |
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