Pembrolizumab Plus Paclitaxel Cisplatin Followed by Surgery for Locally Advanced ESCC
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- STATUS
- Recruiting
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- End date
- Dec 31, 2024
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- participants needed
- 50
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- sponsor
- Tianjin Medical University Cancer Institute and Hospital
Summary
The purpose of this study is to observe and evaluate the efficacy and safety of pembrolizumab plus paclitaxel, cisplatin followed by Da Vinci robot radical surgery for locally advanced esophageal squamous cell carcinoma.
Description
The Preoperative chemoradiotherapy with surgery is the standard treatment in NCCN guideline. But many patients refused or abandon radiotherapy because of the intolerable adverse effects. We designed a single-arm, open-label, phase II trial of pembrolizumab plus paclitaxel, cisplatin followed by Da Vinci robot radical surgery for locally advanced (stage III) esophageal squamous cell cancer. The purpose of this study is to observe and evaluate the efficacy and safety.
Details
| Condition | Esophageal Cancer, Esophageal Cancer, Squamous cell carcinoma, Squamous cell carcinoma, Stage III |
|---|---|
| Age | 18-70 years |
| Treatment | Pembrolizumab Injection [Keytruda] |
| Clinical Study Identifier | NCT04389177 |
| Sponsor | Tianjin Medical University Cancer Institute and Hospital |
| Last Modified on | 19 February 2024 |
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