Retrospective Analysis of Sarcopenia in Older Patients Undergoing Laparotomy
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- STATUS
- Recruiting
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- participants needed
- 200
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- sponsor
- Wirral University Teaching Hospital NHS Trust
Summary
Assess the influence of
Description
Emergency
A number of multivariate risk prediction models exist including POSSUM, P-POSSUM and
APACHE-II with on-going modification of P-POSSUM as part of the National Emergency
. Frailty is the lack of physiological functional reserve and is commonplace in elderly
patients. It has profound effects on the ability to withstand and recover from emergency
Proposal- To assess the utility of psoas major measurement to predict outcomes following
emergency
Methods An analysis of data collected as part of the National Emergency
Demographic, histological, clinical, biochemical and operative data were collected and analysed by accessing patient clinical notes and electronic records.
Outcome measures included inpatient mortality, 30-day mortality and 90-day mortality.
Radiological Analysis Pre-operative CT imaging of the abdomen were accessed and analysed. Cross-sectional images at the level of the L3 inferior end plate were analysed. Cross-sectional area of the psoas major and L3 vertebral body (mm2) were calculated and a ratio of psoas major to L3 cross-sectional area calculated (PML3) . Higher PML3 values indicate higher levels of skeletal muscle mass. Cross-sectional area calculation was conducted using the area of interest tool.
Statistical Analysis Statistical analysis for continuous variables was conducted using Mann-Whitney U test and Chi-squared test for categorical variables. Receiver operating characteristics curves were used for analysis of association of PML3 with mortality.
Multivariate analysis was conducted using binary logistic regression analysis. Logistic regression models were produced including P-POSSUM variables with and without the inclusion of PML3. Receiver operating characteristic analysis of the respective logistic regression models were conducted to assess whether the addition of PML3 enhanced mortality prediction.
Details
Condition |
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---|---|
Age | 65years - 110years |
Treatment |
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Clinical Study Identifier | NCT04493710 |
Sponsor | Wirral University Teaching Hospital NHS Trust |
Last Modified on | 19 February 2024 |
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