Neo-TACE-HAIC for BCLC B Stage HCC (Neoconcept)
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- STATUS
- Recruiting
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- End date
- Dec 30, 2025
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- participants needed
- 280
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- sponsor
- Sun Yat-sen University
Summary
Hepatocellular carcinoma (HCC) patients is a common disease in the East Asia. Although BCLC (Barcelona clinical liver cancer) system recommend to transarterial chemoembolization (TACE) for BCLC B stage patients, increasing studies suggested that hepatic resection provided survival benefit for those patients. However, a relative high recurrence risk leads surgeons to investigate the value of preoperative treatment.
Recently, FOLFOX (Oxaliplatin and 5-fluorouracil) based hepatic artery infusion chemotherapy (HAIC) exhibited high response rate for unresectable HCC.
Pilot study showed TACE combined HAIC (TACE-HAIC) had better tumor response, with low progression disease rate.
Whether TACE-HAIC would improve survival for patients with BCLC B stage is need to further to study. A randomized clinical trial compared neo-TACE-HAIC with surgery versus surgery alone is aimed to answer this question.
Details
| Condition | Adenocarcinoma, Adenocarcinoma, HEPATIC NEOPLASM, liver cancer, HEPATOCELLULAR CARCINOMA, liver cancer |
|---|---|
| Age | 18-75 years |
| Treatment | neo-TACE-HAIC+Surgery, Surgery alone |
| Clinical Study Identifier | NCT04424043 |
| Sponsor | Sun Yat-sen University |
| Last Modified on | 19 February 2024 |
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