Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19

STATUS

Recruiting
participants needed

100
sponsor

Sheba Medical Center

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Updated on 19 February 2024

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covid-19

SARS

ivermectin

viral shedding

acute respiratory syndrome (sars)

Summary

Show definitions

Ivermectin which is an FDA-approved broad spectrum anti-parasitic agent, has also anti-viral activity. In vitro study have shown its activity against SARS-CoV-2, however its clinical effect on patients with COVID-19 never been tested.

In this RCT we would like to evaluate the effect of Ivermectin on reduction of viral shedding among mild to moderate COVID-19 patients, and in shortening the symptom resolution time.

Details

Condition	Covid 19
Age	18years - 80years
Treatment	Ivermectin Oral Product
Clinical Study Identifier	NCT04429711
Sponsor	Sheba Medical Center
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Participants eligible for inclusion will include non-pregnant adult (>18 years
	old) with molecular confirmation of COVID-19. [Participants will be eligible
	in a period of no longer than 72 hours after exposure]
Exclusion Criteria
	Severe infection ( defined as need for invasive or non-invasive ventilator support, ECMO or shock requiring vasopressor support)
	Weight below 40Kg or above 100Kg
	Unable to take oral medication
	Known allergy to the drugs
	Pregnancy or breast feeding
	Participating in another RCT for treatment of COVID-19

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Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19