Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Sheba Medical Center
Updated on 19 February 2024
covid-19
SARS
ivermectin
viral shedding
acute respiratory syndrome (sars)

Summary

Ivermectin which is an FDA-approved broad spectrum anti-parasitic agent, has also anti-viral activity. In vitro study have shown its activity against SARS-CoV-2, however its clinical effect on patients with COVID-19 never been tested.

In this RCT we would like to evaluate the effect of Ivermectin on reduction of viral shedding among mild to moderate COVID-19 patients, and in shortening the symptom resolution time.

Details
Condition Covid 19
Age 18years - 80years
Treatment Ivermectin Oral Product
Clinical Study IdentifierNCT04429711
SponsorSheba Medical Center
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Participants eligible for inclusion will include non-pregnant adult (>18 years
old) with molecular confirmation of COVID-19. [Participants will be eligible
in a period of no longer than 72 hours after exposure]

Exclusion Criteria

Severe infection ( defined as need for invasive or non-invasive ventilator support, ECMO or shock requiring vasopressor support)
Weight below 40Kg or above 100Kg
Unable to take oral medication
Known allergy to the drugs
Pregnancy or breast feeding
Participating in another RCT for treatment of COVID-19
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