Epileptic Activity in Patients With Alzheimer's Disease and Lewy Body Dementia

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Recruiting
participants needed

120
sponsor

Danish Dementia Research Centre

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Updated on 19 February 2024

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depressive symptoms

psychiatric disorder

selective serotonin reuptake inhibitors

functional magnetic resonance imaging

depression

mental disorders

functional mri

alzheimer's disease

mini-mental state examination

ssri

cerebral blood flow

epilepsy

dementia

drugs of abuse

neuropsychological test

neuropsychological assessment

lewy body dementia

lewy body disease

mild depression

illegal drugs

Summary

In the current study, the investigators will examine the extent of subclinical epileptic activity in patients with Alzheimer's disease and patients with Lewy body dementia as compared to healthy elderly controls. The participants will wear a new device called "ear-EEG", which makes it possible to record EEG for longer periods of time while at home. Furthermore, the investigators want to investigate whether there is an association between subclinical epileptic activity and the cerebral blood flow as measured with functional MRI.

Details

Condition	Lewy Body Disease, Epilepsy, Epilepsy, Dementia, Dementia, Alzheimer's Disease, Alzheimer's Disease
Age	50years - 90years
Clinical Study Identifier	NCT04436341
Sponsor	Danish Dementia Research Centre
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Normal cognition as evaluated at the clinical examination
	The participant is a native Danish speaker
	The participant has at least attended school for 7 years
	The participants' hearing and vision is sufficient to participate in neuropsychological tests
	The participants' general condition of health allows that the participant can cooperate with the trial
	The participant does not suffer from psychiatric diseases (except mild depressive symptoms or mild depression) or neurological diseases that affect the brain
	The participant does not have any contraindications for MRI or MRI contrast
Exclusion Criteria
	The participants is suffering from uncontrollable movements of the face as for example oral dyskinesia
	The participant is suffering from epilepsy or receives anti-epileptic medication

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Epileptic Activity in Patients With Alzheimer's Disease and Lewy Body Dementia