This study looks at how well people respond to a vaccine after they have had a special cancer treatment called CARTx. CARTx is used for B-cell malignancies, a type of cancer affecting B-cells, which are part of the immune system. The study will include people who had CARTx and healthy volunteers to compare results. Participants will get a rabies vaccine, which is a shot given to prevent rabies, twice over 6-10 weeks.
Blood samples will be collected before each vaccine, and 1, 2, 4 weeks after, and then 6 months after the first shot to study the immune response.
Participants must be at least 14 years old for CARTx recipients or 18 years for healthy volunteers. Certain health conditions, previous rabies vaccination, or recent treatments can make someone not eligible to join.
- Length of Study: Approximately 6 months.
- Number of Visits: Several visits for vaccinations and blood draws over time.
- Eligibility: Must be healthy or have had CARTx with no major recent health issues.