Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

STATUS

Recruiting
participants needed

100
sponsor

Massachusetts General Hospital

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Updated on 19 February 2024

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functional magnetic resonance imaging

covid-19

coma

vegetative state

minimally conscious state

disorders of consciousness

Summary

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The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness to predict outcome at 3, 6, and 12 months post-hospitalization. We aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery.

Details

Condition	Coma, Depressed Level of Consciousness, COVID19
Age	18years - 100years
Treatment	Functional MRI
Clinical Study Identifier	NCT04476589
Sponsor	Massachusetts General Hospital
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	age 18 or older
	positive diagnosis of COVID-19
	diagnosis of coma, vegetative state or minimally conscious state per Glasgow Coma Scale (GCS) at time of enrollment (excluding confounders such as sedation) and
	clinical team plan for an MRI for clinical management
Exclusion Criteria
	A subject with any of the following MRI contraindications will not be eligible
	for this
	study
	electrical implants such as cardiac pacemakers or perfusion pumps
	ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
	ferromagnetic objects such as jewelry or metal clips in clothing that cannnot be easily removed for scanning
	pregnant volunteers

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Prognostication of Recovery in Early Disorders of Consciousness After COVID-19