Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Massachusetts General Hospital
Updated on 19 February 2024
functional magnetic resonance imaging
covid-19
coma
vegetative state
minimally conscious state
disorders of consciousness

Summary

The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness to predict outcome at 3, 6, and 12 months post-hospitalization. We aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery.

Details
Condition Coma, Depressed Level of Consciousness, COVID19
Age 18-100 years
Treatment Functional MRI
Clinical Study IdentifierNCT04476589
SponsorMassachusetts General Hospital
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

age 18 or older
positive diagnosis of COVID-19
diagnosis of coma, vegetative state or minimally conscious state per Glasgow Coma Scale (GCS) at time of enrollment (excluding confounders such as sedation) and
clinical team plan for an MRI for clinical management

Exclusion Criteria

A subject with any of the following MRI contraindications will not be eligible
for this
study
electrical implants such as cardiac pacemakers or perfusion pumps
ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
ferromagnetic objects such as jewelry or metal clips in clothing that cannnot be easily removed for scanning
pregnant volunteers
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