COVID-19 in Baselland: Investigation and Validation of Serological Diagnostic Assays and Epidemiological Study of Sars-CoV-2 Specific Antibody Responses
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- STATUS
- Recruiting
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- participants needed
- 550
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- sponsor
- University Hospital, Basel, Switzerland
Summary
The study is to investigate the antibody response in the blood and saliva of people with a known COVID-19 infection in the canton of Baselland.
Description
This study is to analyse the antibody response in the blood and saliva of people with a known COVID-19 infection in the canton of Baselland.
The study aims to validate strategies to measure antibody levels with minimal intervention and to explore the antibody response and technical capacity for said measurement. The study will collect the minimally necessary samples to deduce a strategy for serum or saliva surveillance of the population of the canton Baselland. To achieve this, the study is designed to address the following points:
- determine specificity, sensitivity and general utility of point of care (POC) and ELISA tests to deduce a strategy for serum surveillance of the population of the canton Baselland
- especially validate different POC kits in regard of their use for continuous surveillance
- gain an understanding of seroconversion and antibody levels of patients and survivors
- gain an understanding of the individual antibody and T-cell repertoire of patients and survivors
- study whether patterns of convergent antibody evolution is generated in the surviving population or whether the diseases survivors generated an antibody pool recognizing a specific epitope
- develop the technology to correlate blood antibody levels with levels detected in the saliva
- develop high throughput technologies for the precise detection of immune cell Repertoire and binding epitopes
Details
| Condition | COVID-19 Infection |
|---|---|
| Age | 18years - 100years |
| Treatment | Blood Draw, Saliva collection, fingertip tests for POC assays, collection of swabs |
| Clinical Study Identifier | NCT04483908 |
| Sponsor | University Hospital, Basel, Switzerland |
| Last Modified on | 19 February 2024 |
How to participate?
Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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