Low Dose Ruxolitinib in Combination With Methylprednisolone
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- STATUS
- Recruiting
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- participants needed
- 32
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- sponsor
- Chinese PLA General Hospital
Summary
This study is to determine the efficacy and safety of combined Low dose Ruxolitinib With Methylprednisone as Initial Therapy for the aGVHD(acute graft-versus-host disease )
Description
Corticosteroid is used as a first-line treatment for acute GVHD. However, it is effective in only about half of patients. In this prospective study, the investigators prospectively combined low dose ruxolitinib and 1mg/kg methylprednisolone in the initial treatment of acute GVHD. In order to effectively control GVHD without exposing acute GVHD patients to more intense and prolonged immunosuppression, we used ruxolitinib (20mg/day, 10mg/day, 5mg/day, 2.5mg/day) combined with 1mg/kg methylprednisolone. To ally steroid-related complications, we decreased steroid exposure time (39 days) and cumulative methylprednisolone doses (15.4 mg/kg) to spare the associated toxicity of glucocorticoid therapy.
Details
| Condition | Stem Cell Transplant Complications, aGVHD |
|---|---|
| Age | 14-65 years |
| Treatment | Ruxolitinib 10 mg twice a day combined with Corticosteroids, Ruxolitinib 5 mg twice a day combined with Corticosteroids, Ruxolitinib 5 mg once a day combined with Corticosteroids, Ruxolitinib 2.5 mg once a day combined with Corticosteroids |
| Clinical Study Identifier | NCT04397367 |
| Sponsor | Chinese PLA General Hospital |
| Last Modified on | 19 February 2024 |
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