Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    Coordinación de Investigación en Salud, Mexico
Updated on 19 February 2024
cytokines
inflammatory response
covid-19
SARS
antibody titer
acute respiratory syndrome (sars)

Summary

The SARS-CoV-2 infection in the airway epithelium induces cytopathic effects and the cessation of ciliary movement. Increased cytokines and chemokines have been reported to be associated with the severity of the disease. However, most of the molecular and cellular aspects of the inflammatory response and the processes of development of humoral and cellular immunity in these patients are unknown. The aim of this study is characterizing inflammatory processes, seeking to expand the knowledge of the cellular and molecular pathophysiology of COVID-19 that could help in the decision-making of treating health personnel. Mainly, the study is focused on analyzing the inflammatory response by determining cytokines and chemokines. Also, the viral load of the patients with COVID-19 will be determined and will be correlated with the antibody titers. On the other hand, cells will be immunophenotyped to search the cellular depletion profile. Finally, an epidemiological analysis of the patients will be carried out.

Details
Condition SARS-CoV-2
Age 16years - 100years
Treatment Active COVID-19 disease
Clinical Study IdentifierNCT04423640
SponsorCoordinación de Investigación en Salud, Mexico
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients over 16 years old with positive molecular diagnosis of Covid-19, in the Laboratory of IMSS

Exclusion Criteria

Patients with immunosuppressive diseases: HIV +, Hepatitis C virus, primary immunodeficiencies, rheumatoid arthritis, lupus erythematosus and patients under treatment with immunosuppressants
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