Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19
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- STATUS
- Recruiting
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- participants needed
- 200
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- sponsor
- Coordinación de Investigación en Salud, Mexico
Summary
The SARS-CoV-2 infection in the airway epithelium induces cytopathic effects and the cessation of ciliary movement. Increased cytokines and chemokines have been reported to be associated with the severity of the disease. However, most of the molecular and cellular aspects of the inflammatory response and the processes of development of humoral and cellular immunity in these patients are unknown. The aim of this study is characterizing inflammatory processes, seeking to expand the knowledge of the cellular and molecular pathophysiology of COVID-19 that could help in the decision-making of treating health personnel. Mainly, the study is focused on analyzing the inflammatory response by determining cytokines and chemokines. Also, the viral load of the patients with COVID-19 will be determined and will be correlated with the antibody titers. On the other hand, cells will be immunophenotyped to search the cellular depletion profile. Finally, an epidemiological analysis of the patients will be carried out.
Details
| Condition | SARS-CoV-2 |
|---|---|
| Age | 16-100 years |
| Treatment | Active COVID-19 disease |
| Clinical Study Identifier | NCT04423640 |
| Sponsor | Coordinación de Investigación en Salud, Mexico |
| Last Modified on | 19 February 2024 |
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