Genetics of COVID-19 Susceptibility and Manifestations
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- STATUS
- Recruiting
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- End date
- Jun 1, 2025
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- participants needed
- 2500
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- sponsor
- National Human Genome Research Institute (NHGRI)
Summary
- Background
The current SARS-CoV-2 pandemic presents a serious challenge to public health. Some people who are infected with SARS-CoV-2 have mild symptoms or none at all. But others develop severe symptoms, like pneumonia or organ failure. Researchers think that people s genes might play a role in how sick they get. Researchers want to look at the genes of people who have tested positive for COVID-19 to learn more.
- Objective
To learn more about COVID-19 by studying the DNA of people who have tested positive for it, and to share data as fast as possible with other qualified researchers who are also trying to learn more about COVID-19.
- Eligibility
People ages 3 years and older who have tested positive for COVID-19 and are being treated at the NIH Clinical Center or have tested positive through the Occupational Medical Service
- Design
Participants will complete a questionnaire about their health history and COVID-19 symptoms.
Participants will give a blood sample. It will be about 2 tablespoons of blood. Researchers will use this blood sample to study the participant s DNA.
The data about participants genes will be stored in a large database. The database will be shared with other qualified researchers who are trying to learn about COVID-19. Participants names and other personal details will not be shared. Instead, the data will be labeled with a code.
Participants may be contacted by study team members for up to a year after they give their blood sample.
...
Description
The current SARS-CoV-2 pandemic presents a serious challenge to public health. Individuals infected with SARS-CoV-2 experience extremes in symptomatology ranging from a complete lack of symptoms to rapidly worsening end-stage pulmonary disease. The explanatory mechanism underlying susceptibility to severe disease remains unknown. We hypothesize that underlying genetic factors are at least partially explanatory. We aim to employ a phenotypic extremes approach to rapidly ascertain severely and mildly affected COVID-19 patients for genomic interrogation to identify germline and somatic variants that may play a role in host susceptibility to disease to correlate those phenotypic extremes with genetic variants. We will employ both a rare and common variant approach, using both genome sequencing and SNP chip analysis and B and T cell repertoire interrogation.
Details
| Condition | Covid 19, Coronavirus 2019 |
|---|---|
| Age | 3-100 years |
| Clinical Study Identifier | NCT04371432 |
| Sponsor | National Human Genome Research Institute (NHGRI) |
| Last Modified on | 19 February 2024 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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