Early Detection of Cardiac Damage by Two Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Peking University Third Hospital
Updated on 19 February 2024

Summary

The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on twodimensional speckle tracking echocardiography combined with multiple circulating biomarkers.

Description

This is a monocentric prospective cohort study in which 100 patients treated for malignant tumors and with cardiac radiation exposure will be included.All patient will be followed for 12 months after radiotherapy. Echocardiography, 2D STE parameters and circulating biomarkers will be collected.

Details
Condition Radiotherapy, radiotherapeutic
Age 100years or below
Clinical Study IdentifierNCT04443400
SponsorPeking University Third Hospital
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

with malignant tumors
will receive radiotherapy
with cardiac exposure during the radiotherapy process
could receive regular follow-up for 12 months
written informed consent

Exclusion Criteria

satisfactory echocardiographic images could not be obtained
moderate or severe valvular disease
cardiomyopathy
congenital heart disease
refractory hypertension
coronary artery disease
heart failure
arrhythmia requiring intervention
pericarditis
acute myocarditis
participating in other clinical studies of drug intervention
severe liver and kidney dysfunction
autoimmune disease
pulmonary hypertension
coronary artery disease: at least 50% stenosis besed on previous coronary
angiography or CTA, or with a history of percutaneous coronary stent
implantation
with LVEF<50%, unstable anginaor acute myocardial infarction within 3 months
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