Immune Response and Risk of Serious Infection to SARS-Cov2

  • STATUS
    Recruiting
  • participants needed
    63
  • sponsor
    Centre Hospitalier Universitaire Dijon
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Updated on 19 February 2024
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Summary

To date, nearly 2 million people, including at least 100,000 in France, have been infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). This infection is very heterogeneous in nature, ranging from asymptomatic forms to acute respiratory distress syndrome patterns in 6.1% of cases, leading to an estimated overall mortality of 5.2%.

Apart from age, few risk factors for a pejorative evolution have been identified: arterial hypertension, diabetes, cardiovascular history, obesity and chronic respiratory pathology in particular. The median incubation period is 5 days and the median time between the appearance of the first symptoms and the onset of hypoxia requiring admission to intensive care is 7 to 12 days. The mechanisms involved in the occurrence of these secondary worsening patterns are unclear. One hypothesis is that it is related to an inappropriate inflammatory response rather than a direct cytopathic effect of the virus. The objective of this study is to measure the intensity of the T lymphocyte response in patients hospitalized for Cov2 SARS infection in order to determine whether the intensity of the response is associated with worsening of symptoms.

Details
Condition SARS Cov2, Immune Response
Age 18years - 100years
Treatment Blood Sample collection
Clinical Study IdentifierNCT04410432
SponsorCentre Hospitalier Universitaire Dijon
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Person having given his or her non-opposition
Patient hospitalized with an SARS-Cov2 infection proven by virological sampling (nasopharyngeal or sputum PCR) less than 72 hours old

Exclusion Criteria

Person subject to a legal protection measure (curatorship, guardianship)
Person subject to a safeguard measure of justice
Pregnant, parturient or breastfeeding woman
Major incapable or incapable of giving consent
Minor
Clear my responses
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