Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
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- STATUS
- Recruiting
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- participants needed
- 100
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- sponsor
- Chinese Medical Association
Summary
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Details
| Condition | Family, Aneurysm, Aneurysm, Aortic Dissection, Familial, With or Without Aortic Aneurysm |
|---|---|
| Age | 100years or below |
| Treatment | movement |
| Clinical Study Identifier | NCT04439565 |
| Sponsor | Chinese Medical Association |
| Last Modified on | 19 February 2024 |
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