Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.
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- STATUS
- Recruiting
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- participants needed
- 60
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- sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Summary
The primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis. To ascertain this issue, we evaluated:
- Changes in receptor polymorphism (ACE2 and CD26 receptor study.
- SARS-CoV-2 CD4/CD8 T cell response (CTL)
- Different KIR phenotypes
Description
Only 24% of health care workers (HCW) had developed inmunological response to SARS CoV-2 infection in one centre attending thousands of COVID-19 patients, and with shorteness of personal protective equipments. Our hypothesis is that this relatively low number of infected HCW could be secondary to:
- Differences in susceptibility to infection mediated by changes in viral receptors. Thus, it is important to characterize and genotyping the main receptor for SARS-CoV-2, ACE2, and other related receptor, such as CD26.
- Increased cellular immune response, offering cross-immunity against SARS CoV-2 infection by previous exposure to other coronavirus or respiratory pathogens. A specific CD4/CD8 T cell response to viral peptides could respond this question
- Specific KIR phenotypes (Killer Immunoglobulin-like Receptors): Natural killer cells (NK) response to alterations of class I HLA molecules presented in infected cells. An increase in class I HLA expression could lead to an increase in NK activation by increasing its ability to produce IFN-gamma.
Details
| Condition | Transmission, Dentist-Patient, Diathesis, Immune Response, Receptor Site Alteration |
|---|---|
| Age | 18-65 years |
| Treatment | Susceptibility to infection |
| Clinical Study Identifier | NCT04402827 |
| Sponsor | Asociacion para el Estudio de las Enfermedades Infecciosas |
| Last Modified on | 19 February 2024 |
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