Efficacy and Safety of JMT101 Combined With Afatinib (or Osimertinib) in Patients With Non-Small Cell Lung Cancer
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- STATUS
- Recruiting
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- participants needed
- 48
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- sponsor
- Shanghai JMT-Bio Inc.
Summary
This study is a Phase Ib, open label, multi-center study of to evaluate the safety and efficacy of JMT101 combined with EGFR-TKIs (Afatinib or Osimertinib) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations.
Description
The objective of the trial is to evaluate the safety and efficacy of JMT101 combined with EGFR-TKIs (afatinib or osimertinib) in patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations.
This study consists of two parts (Stage I and Stage II). Stage I was a dose escalation study, and Stage II was a dose expansion study.
Details
| Condition | Locally Advanced or Metastatic Non-Small Cell Lung Cancer |
|---|---|
| Age | 18-75 years |
| Treatment | JMT101 |
| Clinical Study Identifier | NCT04448379 |
| Sponsor | Shanghai JMT-Bio Inc. |
| Last Modified on | 19 February 2024 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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