Gender Identity and Own Body Perception

  • STATUS
    Recruiting
  • participants needed
    150
  • sponsor
    University of California, Los Angeles
Updated on 19 February 2024
hormone therapy
sex hormones
dysphoria

Summary

This study will provide valuable information on the neurobiological underpinning of gender dysphoria (GD) and the effects of sex hormones, and promises to uncover functional or structural neural patterns that could predict outcome in terms of body image and quality of life after cross-sex hormone treatment.

Description

The purpose of this study is to understand the neurobiology of gender dysphoria (GD) and the interactions between cross hormone treatment, the brain, and the body phenotype. The investigators also aim to identify pre-treatment neurobiological and other factors to help predict body congruence and quality of life outcomes from hormone treatment. There is mounting interest in gender identity issues worldwide, as requests for gender-confirming treatments have increased in the past 3 decades, and alarmingly high suicide rates have recently been reported in those with GD. Despite this, little is known about neurobiological or other etiological factors contributing to GD or gender incongruence. This study will address a core feature of GD that has been little studied in terms of the neurobiology: the incongruence between perception of self and one's own body.

Details
Condition Gender Dysphoria
Age 18years - 40years
Treatment fMRI
Clinical Study IdentifierNCT04374708
SponsorUniversity of California, Los Angeles
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Females and males from any racial or ethnic background, between the ages of 18 and 40
IQ > 80
Control participants

Exclusion Criteria

Psychiatric medications
A score of 1 standard deviation higher than population norms on the MADRS depression or the Hamilton anxiety scale (HAMA)
Sex hormone treatment
Irregular menstrual cycles
Exclusion criteria for all participants
Any known chromosomal or hormonal disorder
Current substance abuse or dependence
Current neurological disorder or psychiatric disorder
Pregnancy
Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders
Head trauma associated with loss of consciousness
HIV positive individuals
Individuals with ferromagnetic metal implantations or devices. This includes any electronic implants or devices, braces, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates
Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart. Acuity may be met with corrective lenses
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