TMAO in Patients With Severe Aortic Stenosis
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- STATUS
- Recruiting
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- participants needed
- 70
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- sponsor
- Medical University of Warsaw
Summary
Trimethylamine N-oxide (TMAO) has recently gained increasing scientific interest in the field of cardiovascular disease, including its role in cell protection against osmotic and hydrostatic stress. Aortic stenosis (AS) is the most common valvular heart disease, affecting about 7.6 million people over 75 years of age in North America and Europe alone. We hypothesized that TMAO plays a role in protection of the cardiomyocytes against pressure overload in patients with AS. The primary aim of this study is to assess the correlation between the serum and urine TMAO concentration, and (i) echocardiographic, (ii) biochemical and (iii) histopathological parameters of heart failure in patients with severe AS. The secondary aim of this study is to evaluate a correlation between the baseline TMAO concentrations and the post-treatment clinical status, as well as the post-treatment echocardiographic and biochemical parameters.
Details
| Condition | Aortic Stenosis, Heart failure, Heart failure, Heart disease, Heart disease, VALVULAR HEART DISEASE |
|---|---|
| Age | 18-99 years |
| Treatment | Measurement of plasma and urine trimethylamine-N-oxide concentration |
| Clinical Study Identifier | NCT04406805 |
| Sponsor | Medical University of Warsaw |
| Last Modified on | 19 February 2024 |
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