Combination Immunotherapy Targeting Sarcomas
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- STATUS
- Recruiting
-
- participants needed
- 20
-
- sponsor
- Shenzhen Geno-Immune Medical Institute
Summary
The aim of this clinical trial is to assess the feasibility, safety and efficacy of a combination low dose chemotherapy and immunotherapy in patients who have sarcoma that is relapsed or late staged. Another goal of the study is to assess the safety and efficacy of the therapy that combines multiple CAR T cells followed by sarcoma vaccines.
Description
Patients with late staged and/or recurrent sarcoma have poor prognosis despite complex multimodal therapy. Therefore, innovative interventions are needed. Sarcoma is known to express increased levels of surface antigens that can be targeted by CAR-T cells. In addition, studies have shown that low dose chemotherapy such as doxorubicin may modulate surface PD-L1 level and enhance immunotherapy effects. This study will combine multiple CAR T cells with low dose chemotherapy to treat sarcoma, and followed by maintenance sarcoma vaccines. The purpose of this clinical trial will assess the feasibility, safety, efficacy and side effects of this combination therapy in patients who have sarcoma that is relapsed or late staged.
Details
| Condition | Connective and Soft Tissue Neoplasm, Solid Tumors, Ewing's sarcoma, Osteosarcoma, Osteosarcoma, Sarcoma, Sarcoma, Solid Tumors |
|---|---|
| Age | 1-75 years |
| Treatment | Multiple sarcoma-specific CAR-T cells and sarcoma vaccines |
| Clinical Study Identifier | NCT04433221 |
| Sponsor | Shenzhen Geno-Immune Medical Institute |
| Last Modified on | 19 February 2024 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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