The TARGET-EFT Trial

  • STATUS
    Recruiting
  • participants needed
    144
  • sponsor
    Jonathan Afilalo
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Updated on 19 February 2024
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anemia
malnutrition

Summary

Randomized clinical trial to determine whether a multicomponent intervention will lead to improvements in mobility, self-care, mood, pain, and physical activity among frail and pre-frail older adults (as measured with the Essential Frailty Toolset; EFT) hospitalized for an acute cardiovascular illness.

Description

The investigators will conduct a single-center randomized clinical trial at the Jewish General Hospital; an academic tertiary care center in Montreal, Quebec. Researchers will pre-screen stable patients 65 years of age admitted to the cardiovascular unit. The investigators will target those that consent and have evidence of frailty or pre-frailty according to the EFT (score 1/5). The EFT consists of a chair rise test to screen for physical frailty, a mini-cog test to screen for cognitive impairment, a hemoglobin level and a serum albumin level. Patients will be randomly allocated to the usual-care control group, or the intervention group that will receive targeted treatments depending on the EFT deficits identified. All patients will be outfitted with a hip-worn accelerometer to monitor position, step count, and sleep data during the study period. Patients will undergo a structured questionnaire and physical performance assessment at baseline (upon index admission) and at discharge, and will be contacted by telephone 30 days post-discharge to assess their recovery. The primary endpoint will be represented by the EQ-5D scale (mobility, self-care, mood, pain, and physical activity) measured by blinded observers.

Details
Condition Quality of life, Frailty, Cardiovascular Diseases in Old Age, Geriatric Cardiology
Age 65years - 100years
Treatment Physical Component of the Intervention, Cognitive Component of the Intervention, Nutritional Component of the Intervention, Iron-Deficiency Anemia (IDA) Component of the Intervention
Clinical Study IdentifierNCT04291690
SponsorJonathan Afilalo
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 65 years
Frail or pre-frail as defined by EFT score 1
Admission to the JGH cardiovascular unit
Signed informed consent

Exclusion Criteria

Expected discharge within <3 days
Clinically unstable (unstable vital signs, low-threshold coronary ischemia, uncontrolled heart failure, uncontrolled arrhythmia)
Awaiting cardiac surgery during the index hospitalization
Severe dementia (MMSE 10/30)
Delirium (CAM positive)
Psychiatric condition precluding cooperation
Not English or French speaking
Parkinson's disease
Recent stroke <7 days
Bed-bound or paraplegic
End-of-life care plan
Clear my responses
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