The TARGET-EFT Trial
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- STATUS
- Recruiting
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- participants needed
- 144
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- sponsor
- Jonathan Afilalo
Summary
Randomized clinical trial to determine whether a multicomponent intervention will lead to improvements in mobility, self-care, mood, pain, and physical activity among frail and pre-frail older adults (as measured with the Essential Frailty Toolset; EFT) hospitalized for an acute cardiovascular illness.
Description
The investigators will conduct a single-center randomized clinical trial at the Jewish General Hospital; an academic tertiary care center in Montreal, Quebec. Researchers will pre-screen stable patients 65 years of age admitted to the cardiovascular unit. The investigators will target those that consent and have evidence of frailty or pre-frailty according to the EFT (score 1/5). The EFT consists of a chair rise test to screen for physical frailty, a mini-cog test to screen for cognitive impairment, a hemoglobin level and a serum albumin level. Patients will be randomly allocated to the usual-care control group, or the intervention group that will receive targeted treatments depending on the EFT deficits identified. All patients will be outfitted with a hip-worn accelerometer to monitor position, step count, and sleep data during the study period. Patients will undergo a structured questionnaire and physical performance assessment at baseline (upon index admission) and at discharge, and will be contacted by telephone 30 days post-discharge to assess their recovery. The primary endpoint will be represented by the EQ-5D scale (mobility, self-care, mood, pain, and physical activity) measured by blinded observers.
Details
| Condition | Quality of life, Frailty, Cardiovascular Diseases in Old Age, Geriatric Cardiology |
|---|---|
| Age | 65-100 years |
| Treatment | Physical Component of the Intervention, Cognitive Component of the Intervention, Nutritional Component of the Intervention, Iron-Deficiency Anemia (IDA) Component of the Intervention |
| Clinical Study Identifier | NCT04291690 |
| Sponsor | Jonathan Afilalo |
| Last Modified on | 19 February 2024 |
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