A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer
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- STATUS
- Recruiting
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- participants needed
- 36
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- sponsor
- H3 Biomedicine Inc.
Summary
The primary objective of this study is to evaluate the safety and tolerability of H3B-6545 and palbociclib when administered in combination in order to determine the maximum tolerated dose (MTD) and/or the recommended Phase 2 dose (RP2D) of this combination in women with advanced or metastatic estrogen receptor-positive (ER+) HER2- breast cancer.
Details
| Condition | Breast Cancer, Breast Cancer, ERBB2 gene, estrogen receptor |
|---|---|
| Age | 18years - 100years |
| Treatment | Palbociclib (75, 100, 125 milligram [mg]), H3B-6545 (300, 450 mg) |
| Clinical Study Identifier | NCT04288089 |
| Sponsor | H3 Biomedicine Inc. |
| Last Modified on | 19 February 2024 |
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