Collection of Biological Samples From Patients Treated With CAR-T Cells for Hematological Malignancies
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- STATUS
- Recruiting
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- End date
- Feb 25, 2035
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- participants needed
- 300
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- sponsor
- University Hospital, Montpellier
Summary
Development of CAR-T cell against CD19 B lymphoma and Acute Lymphoblastic Leukemia leaded to 2 authorized medication: Yescarta and Kymriah. Despite impressive outcomes in 3 phase II studies, never met in relapsed or refractory diseases, half of the patients don't respond to this treatment.This can be explained by a low expansion, functional alteration or short persistence of infused cells. Determination of reasons for treatment failure is the first step for optimization of this therapeutics. This project aims to bank blood samples from a cohort of patients treated with CAR-T cell for hematological malignancies in Montpellier University Hospital. Clinical data related to samples will be collected. This samples will be used to determine factors influencing efficacy of CAR-T cells treatments.
Description
Development of CAR-T cell against CD19 B lymphoma and Acute Lymphoblastic Leukema leaded to 2 authorized medication: Yescarta and Kymriah. Despite impressive outcomes in 3 phase II studies, never met in relapsed or refractory diseases, half of the patients don't respond to this treatment.This can be explained by a low expansion, functional alteration or short persistance of infused cells. Determination of reasons for treatment failure is the first step for optimization of this therapeutics. This project aims to bank blood samples from a cohort of patients treated with CAR-T cell for hematological malignancies in Montpellier University Hospital. Clinical data related to samples will be collected. This samples will be used to determine factors influencing efficacy of CAR-T cells treatments.
Details
| Condition | Lymphoma and Acute Lymphoblastic Leukemia |
|---|---|
| Age | 18years - 100years |
| Treatment | additional biological samples during CAR-T CELL treatment |
| Clinical Study Identifier | NCT04290000 |
| Sponsor | University Hospital, Montpellier |
| Last Modified on | 19 February 2024 |
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