Using Direct Brain Stimulation to Study Cognitive Electrophysiology
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- STATUS
- Recruiting
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- participants needed
- 250
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- sponsor
- University of Pennsylvania
Summary
This project forms a multi-site research collaboration to carry out verbal and spatial memory experiments in patient volunteers to better understand the neural bases of human memory, employing direct electrical brain stimulation as a tool to study those dynamics and their relationship to memory performance.
Description
The study protocol outlines fundamental experiments to understand the neural dynamics underlying human memory and use direct brain stimulation as a tool (intervention) to study the relationship between those dynamics and memory performance. The investigators will collect recording and stimulation data from 250 patient volunteers as they perform carefully-matched verbal and spatial memory tasks. During non-stimulation sessions, the investigators will measure correlative neural biomarkers of memory encoding and retrieval using standard clinical depth electrodes and micro-wire recordings. To test the causal role of these biomarkers, the investigators will employ direct brain stimulation to briefly modulate neural activity, and measure ensuing changes in behavioral performance. With a set of causal biomarkers and predictive models in hand, the investigators will finally ask whether model-driven stimulation paradigms offer the investigators the ability to reliably modulate neural activity, and consequent behavior, in real-time.
Details
| Condition | Epilepsy Intractable |
|---|---|
| Age | 18years - 65years |
| Treatment | Direct electrical stimulation |
| Clinical Study Identifier | NCT04286776 |
| Sponsor | University of Pennsylvania |
| Last Modified on | 19 February 2024 |
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