Effect of Different Treatments on the Prognosis of Early Cervical Cancer: A Multicenter Prospective Real-world Study

  • STATUS
    Recruiting
  • End date
    Jan 1, 2026
  • participants needed
    20000
  • sponsor
    Southern Medical University, China
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Updated on 19 February 2024
See if I qualify
cancer
hysterectomy
squamous cell carcinoma
adenocarcinoma
carcinoma
uterine cervix
adjuvant therapy
adenosquamous carcinoma
cervical disease
cervical carcinoma
iia2
cervical cancer

Summary

To observe the effects of different treatments on the oncological outcome and complications of early cervical cancer (2018 FIGO stage IA1 with lymphovascular space invasion and IA2-IIA2 cervical cancer). This study prospectively collecting enrolled cervical cancer patients clinical data and outcome from June 2020 to June 2025. (Classification factors: preoperative neoadjuvant treatment , surgical approach, type of hysterectomy, whether to receive radiochemotherapy) . This study is an observational study, and segmented analysis according to different treatment methods.

Description

Objectives: To observe the effects of different treatments on the oncological outcome and complications of early cervical cancer (2018 FIGO stage IA1 with lymphovascular space invasion and IA2-IIA2 cervical cancer).

Study Design: We obtained the demographic, clinical, treatment hospital and complication data of patients with cervical cancer undergoing radical hysterectomy from 2004 to 2015 at 37 hospitals. The patients were assigned into groups. Classification factors: preoperative neoadjuvant treatment (not received, neoadjuvant chemotherapy, preoperative radiotherapy) , surgical approach (abdomincal, laparoscopic, vaginal, robotic surgery), type of hysterectomy (type B, type C1, type C2), primary treatment (radiochemotherapy or surgery).

laparoscopic and abdominal surgery groups. The differences in the survival, complication rates, quality of life, and cost were analyzed using univariate and multivariable logistic regression models.

Details
Condition Cervical Cancer, Cervical Cancer, Uterine Cancer, Uterine Cancer
Age 18years - 100years
Treatment clinical routine treatments
Clinical Study IdentifierNCT04272190
SponsorSouthern Medical University, China
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Histologically confirmed primary adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, or other histological types carcinoma of the uterine cervix
Patients with Histologically confirmed stage IA1 (with lymph vascular invasion), FIGO 2018 stage IA2 to IIA2
Underwent radical hysterectomy or radiochemotherapy
ECOG Performance Status of 0 or 1

Exclusion Criteria

Life expectancy is less than 6 months
No prior malignancy
ECOG Performance Status of 2 to 5
Clear my responses
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cancer
hysterectomy
squamous cell carcinoma
adenocarcinoma
carcinoma
uterine cervix
adjuvant therapy
adenosquamous carcinoma
cervical disease
cervical carcinoma
iia2
cervical cancer

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