L-TIL in Patients With Malignancy Resistance to Anti-PD-1 Therapy

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Henan Cancer Hospital
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Updated on 19 February 2024
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Summary

Safety and effectiveness of liquid tumor infiltrating lymphocytes in patients with advanced malignant tumors who have failed to anti-PD-1 therapy

Details
Condition Advanced Solid Tumor
Age 18years - 70years
Treatment liquid tumor infiltrating lymphocytes
Clinical Study IdentifierNCT04268108
SponsorHenan Cancer Hospital
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Expected lifespan is over 3 months
malignant tumors diagnosed by pathological examination
Imaging examination is at advanced stage with at least one measurable lesion
Ineffective or resistant to previous anti-PD-1 therapy
ECOG score 0-2
Adequate organ function
No other serious diseases that conflict with this protocol
Women of childbearing age must check for a negative blood pregnancy test within 7 days, and subjects of childbearing age must use appropriate contraception during the test and within 3 months
witten informed consent from the patients

Exclusion Criteria

Severe infectious disease within 4 weeks before enrollment
Active hepatitis B or C virus or HIV infection
Severe autoimmune disease or immunodeficiency disease
Severe allergies
Severe mental disorder
Systematically used a large amount of glucocorticoids within 4 weeks before enrollment
With severe heart, liver, kidney insufficiency, diabetes and other diseases
Participation in other clinical studies in the past 3 months or having been treated with other gene products
Clear my responses
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