Gestational Diabetes

  • STATUS
    Recruiting
  • End date
    May 1, 2028
  • participants needed
    800
  • sponsor
    University Hospital Tuebingen
Updated on 19 February 2024
insulin
diabetes
blindness
type 2 diabetes mellitus
antidiabetic agents
non-traumatic amputation
niddm

Summary

Due to a changed lifestyle with less physical activity, unfavorable diets rich in fat and calories and obesity, the prevalence of diabetes mellitus is increasing worldwide. The diabetes epidemic is associated with significant personal and socio-economic consequences. Despite attempts to prevent the complications of diabetes, this disease is still the leading cause of blindness, chronic renal insufficiency and non-traumatic amputation. It is important to detect early on an increase in blood sugar and treat it accordingly to reduce costs and to minimize the personal suffering of those affected. As the number of patients with type 2 diabetes mellitus continues to rise, the number of young women with gestational diabetes mellitus (GDM) also increases. This is a disorder og glucose metabolism, which occurs for the first time in pregnancy. The causes for this are manifold. Among other causes, the increasing age of the mothers and weight gain during pregnancy are risk factors for gestational diabetes. Although it has been recommended that women with gestational diabetes should be re-examined after the birth of their child, many women have not. The study is a follow-up study to clarify whether insulin secretion disorder in women with and after GDM is a risk factor for the occurrence of type 2 diabetes mellitus.

Details
Condition Gestational Diabetes, Diabetes Mellitus, Pregnancy Complications, Pregnancy Complications
Age 18-100 years
Clinical Study IdentifierNCT04270578
SponsorUniversity Hospital Tuebingen
Last Modified on19 February 2024

Eligibility

Yes No Not Sure

Inclusion Criteria

Signed and dated informed consent
Enrollment is possible during AND after gestation
Baseline visit (pregnancy): gestational week 24+0 till 31+6
Postpartum visits: documented occurence of GDM in previous pregnancy

Exclusion Criteria

Age < 18years
Diabetes Mellitus Type 1 or Type 2
GFR < 60 ml/min/1,73 m2
CRP > 1 mg/dl
Increased levels of transaminases 2 fold above ULN
Preexisting cardiac conditions
Weight loss > 10% within 6 months prior to inclusion
Psychiatric disorders
Chronic alcohol or substance abuse
Blood sugar increasing or decreasing drug therapy, e.g. steroids, antidiabetics, insulin
only postpartum visits: pregnancy or lactation
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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