Effects of Brain Stimulation on Cognition Oscillations and GABA Levels in Schizophrenia
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- STATUS
- Recruiting
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- participants needed
- 160
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- sponsor
- University of California, Davis
Summary
The purpose of this study is to use a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to test a set of hypotheses about the role of the prefrontal cortex in behavioral and neural correlates of cognition in schizophrenia. Behavioral, electrophysiological (EEG) and neuroimaging measures will be used to assess cognitive performance. This study has three main goals: (1) To compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in schizophrenia; (2) To establish the regional specificity of the impact of DLPFC tDCS (compared to Occipital tDCS) effects on brain circuitry underlying goal maintenance in schizophrenia; (3) To examine relationships between tDCS effects on DLPFC GABA levels, DLPFC-related oscillatory activity and cognitive performance in schizophrenia. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.
Details
| Condition | Schizophrenia |
|---|---|
| Age | 18-35 years |
| Treatment | Transcranial direct current stimulation |
| Clinical Study Identifier | NCT04267003 |
| Sponsor | University of California, Davis |
| Last Modified on | 19 February 2024 |
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