Effects of Brain Stimulation on Cognition Oscillations and GABA Levels in Schizophrenia

  • STATUS
    Recruiting
  • participants needed
    160
  • sponsor
    University of California, Davis
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Updated on 19 February 2024
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antipsychotics
brain stimulation
transcranial direct current stimulation
schizophrenia
schizoaffective disorder
clozapine
task performance

Summary

The purpose of this study is to use a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to test a set of hypotheses about the role of the prefrontal cortex in behavioral and neural correlates of cognition in schizophrenia. Behavioral, electrophysiological (EEG) and neuroimaging measures will be used to assess cognitive performance. This study has three main goals: (1) To compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in schizophrenia; (2) To establish the regional specificity of the impact of DLPFC tDCS (compared to Occipital tDCS) effects on brain circuitry underlying goal maintenance in schizophrenia; (3) To examine relationships between tDCS effects on DLPFC GABA levels, DLPFC-related oscillatory activity and cognitive performance in schizophrenia. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.

Details
Condition Schizophrenia
Age 18years - 35years
Treatment Transcranial direct current stimulation
Clinical Study IdentifierNCT04267003
SponsorUniversity of California, Davis
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Participants must be able to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
All subjects must have the ability to give valid informed consent
Inclusion Criteria for Patients with Schizophrenia Only
Diagnosis of schizophrenia, schizophreniform or schizoaffective disorder
No medication changes in the prior month
No medication changes anticipated in the upcoming month
Stable outpatient or partial hospital status
Normal IQ (>70; IQ will be measured by administering the Wechsler Abbreviated Scale of
Intelligence (WASI) test)
Must not be currently taking the antipsychotic clozapine

Exclusion Criteria

Pacemakers
Implanted electrical (brain and spinal) stimulators
Implanted defibrillator
Metallic implants
Skin damage or skin conditions such as eczema at the sites where electrodes will be placed
Hair styles hindering the placement of electrodes
Cranial pathologies
Head trauma
Epilepsy
Mental retardation
Any known history of neurological disorders (including epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, cerebral palsy, any DSM-5 axis I psychiatric disorder (for healthy control subjects), autism)
Uncorrected vision problems that would hinder cognitive testing (this also pertains to subjects with color blindness in tasks where discriminating colored objects/items is necessary for successful performance)
Pregnancy
Substance dependence in the past six months
Substance abuse in the past month
Clear my responses
Read more

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antipsychotics
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clozapine
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