Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
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- STATUS
- Recruiting
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- days left to enroll
- 47
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- participants needed
- 699
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- sponsor
- AstraZeneca
Summary
A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
Description
This Phase III study will assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
Target patient population: Adult female patients with histologically confirmed diagnosis of epithelial endometrial carcinoma (excluding sarcomas): newly diagnosed Stage III, newly diagnosed Stage IV, or recurrent endometrial cancer
Details
| Condition | Endometrial Carcinoma, Uterine Cancer, Uterine Cancer |
|---|---|
| Age | 18-150 years |
| Treatment | Carboplatin, Paclitaxel, Durvalumab, Olaparib, durvalumab placebo, olaparib placebo |
| Clinical Study Identifier | NCT04269200 |
| Sponsor | AstraZeneca |
| Last Modified on | 19 February 2024 |
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