Effects of NAD3 Supplementation on Biomarkers of Aging

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Recruiting
participants needed

54
sponsor

The Center for Applied Health Sciences, LLC

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Updated on 19 February 2024

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body mass index

systolic blood pressure

fatigue

Summary

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This is a randomized, parallel-group, placebo-controlled, clinical trial in middle-aged and older male and female subjects from Ohio. Subjects will take an over-the-counter dietary supplement or a placebo for 12 weeks. Outcome measures will include body weight, systolic and diastolic blood pressure, standard blood chemistries (e.g. chemistry panel, lipid panel, CBC with differential), changes in mood, vitality, energy, fatigue, productivity, digestive wellness (via anchored Visual Analogue Scales).

Details

Condition	Senility
Age	40years - 60years
Treatment	NAD3
Clinical Study Identifier	NCT04276948
Sponsor	The Center for Applied Health Sciences, LLC
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Provide voluntary signed and dated informed consent
	Be in good health as determined by medical history, physical, and routine blood chemistries
	Age between the ages of 40 and 60 (inclusive)
	Body Mass Index (BMI) of 18.5-34.9 kg/m2 (normal to Class I obesity)
	Normotensive (supine, resting systolic blood pressure <140 mm Hg and diastolic blood pressure < 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5 minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility
	Normal supine, resting heart rate (<90 per minute)
	Willing to duplicate their previous 24-hour diet, and fast for 10 hours prior each of the treatments
Exclusion Criteria
	History of uncontrolled diabetes
	Regular use/consumption (i.e. at least 5 days/week) of resveratrol, quercetin, pterostilbene coQ10, grapefruit, nicotinamide riboside, probiotics, prebiotic fiber, green tea, niacin (vitamin B3), multivitamin/multimineral or products meant to promote "healthy aging" or "anti-aging" or "longevity" products in the 2 weeks prior to screening as well as throughout the study
	Clinically significant abnormal blood work at screening
	Consumption of > 2 alcoholic drinks per day
	History of malignancy in the previous 5 years except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin)
	Other known gastrointestinal or metabolic diseases that might impact nutrient absorption or metabolism, e.g. short bowel syndrome, diarrheal illnesses, history of colon resection, gastro paresis, Inborn-Errors-of-Metabolism (such as PKU)
	Chronic inflammatory condition/disease or unstable medical condition (e.g. rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, hepatitis, HIV/AIDS, etc.)
	Known sensitivity to any ingredient in the test formulations as listed in the Certificates-of-Analysis
	Currently participating in another research study with an investigational product or have been in another research study in the past 30 days
	History of drug or alcohol addiction or abuse within 1 year prior to screening
	Treatment with any known enzyme-altering drugs such as barbiturates, glucocorticoids, macrolides, antidepressants, neuroleptics, imidazoles, or fluoroquinolones within 30 days prior to screening
	Subjects who (for whatever reason) have been on a self-restricted diet, controlled diet or special therapeutic diet, or who have had substantial changes in eating habits within 30 days prior to screening
	Donation of blood within 30 days or plasma within 7 days, prior to screening
	History or presence of clinically significant diseases or conditions (e.g., cardiovascular, pulmonary, respiratory, hepatic, renal, hematological, gastrointestinal, endocrine, immunologic, dermatologic, neurological, or psychiatric) which, in the opinion of the medical staff, could confound the primary endpoints or place the subject at increased risk of harm if they were to participate

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Effects of NAD3 Supplementation on Biomarkers of Aging