Thoracic Re-irradiation For Locoregionally Recurrent Non-small Cell Lung Cancer
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- STATUS
- Recruiting
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- End date
- Feb 1, 2025
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- participants needed
- 35
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- sponsor
- Sun Yat-sen University
Summary
This prospective phase II study is to assess the efficacy and safety of thoracic re-irradiation for locoregionally recurrent non-small cell lung cancer using hypofractionated technique.
Description
This prospective phase II study is to assess the efficacy and safety of thoracic re-irradiation for locoregionally recurrent non-small cell lung cancer using hypofractionated technique.
- For peripherally located recurrent tumors, stereotactic body radiation therapy is used at 5000-6000 cGy in 10 fractions.
- For centrally located recurrent tumors, adaptive hypofractionated radiation is used: Patients are irradiated at 3000-4000cGy in 6-10 daily fractions in the first course. After a four-week interval, patients who have non-progressive disease and an adequate pulmonary function undergo adaptive re-planning, and are irradiated at 2400-3500cGy in 4~7 daily fractions as a boost. Concurrent chemotherapy consists of weekly docetaxel and nedaplatin.
Details
| Condition | Loco-regionally Recurrent NSCLC After Thoracic Radiotherapy |
|---|---|
| Age | 18-75 years |
| Treatment | thoracic irradiation, Concurrent chemotherapy |
| Clinical Study Identifier | NCT04275687 |
| Sponsor | Sun Yat-sen University |
| Last Modified on | 19 February 2024 |
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