Flu-Bu-Mel Conditioning Regimen for Myeloid Disease
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- STATUS
- Recruiting
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- participants needed
- 50
-
- sponsor
- Shanghai Jiao Tong University School of Medicine
Summary
For patients with acute myeloid leukemia (AML) or myelodyspasia syndrome undergoing allo-HSCT, the conditioning regimen will be 5-day Fludarabine, 2-day Busulifan and 2-day melphalan
Description
For patients with acute myeloid leukemia (AML) or myelodyspasia syndrome undergoing allo-HSCT, the conditioning regimen will be Fludarabine (30mg/m2, d-7 to d-3) + Busulifan 3.2mg/kg (d-7 to d-6) + melphalan 70mg/m2 (d-4 and d-3). The GVHD prophylaxis will be PT-CY (Cyclophosphamide 50mg/kg d+3 and d+4) + low-dose ATG (2.5mg/kg) on d+15.
Details
| Condition | Relapse Rate After Allo-HSCT |
|---|---|
| Age | 16-65 years |
| Treatment | Flu-Bu-Mel |
| Clinical Study Identifier | NCT04269811 |
| Sponsor | Shanghai Jiao Tong University School of Medicine |
| Last Modified on | 19 February 2024 |
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