Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease Treatment

  • STATUS
    Recruiting
  • participants needed
    900
  • sponsor
    Hospital de Niños R. Gutierrez de Buenos Aires
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Updated on 19 February 2024
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pharmacological treatment
chagas
parasitemia
nifurtimox
benznidazole

Summary

Chagas disease is caused by parasite Trypanosoma Cruzi. In Argentina, there is an estimated of 1.600.000 infected people. Due to migration phenomenon, most cases live in urban areas without vectorial transmission.

Pharmacological treatment is given to prevent development of cardiac and gastrointestinal sequelae. There are two available drugs for this disease; Nifurtimox and Benznidazole. They both has proven efficacy for acute face treatment, with different security profiles. There are not enough adequate studies comparing both drugs made in a large number of subjects. Investigators will study 900 patients treated with both drugs and compare security and efficacy in a retrospective cohort.

Details
Condition Chagas' disease
Age 18years or below
Treatment Clinical Manifestations, Serologic response, Direct method, Adverse events
Clinical Study IdentifierNCT04274101
SponsorHospital de Niños R. Gutierrez de Buenos Aires
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients between 0 and 18 years of age with confirmed Chagas disease (defined as patients under 8 months with positive parasitemia or older with 2 positive different techniques for serology) that received treatment with Nifurtimox or Benznidazole

Exclusion Criteria

Patients that abandoned follow-up
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