The Anti-inflammatory Effects of Hark ny Medicinal Water

STATUS

Recruiting
participants needed

350
sponsor

University of Pecs

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Updated on 19 February 2024

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renal disease

arthritis

psoriasis vulgaris

skin lesion

psoriasis

Summary

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The study aims to provide evidence on the effectiveness of Harkny medicinal water in psoriatic and rheumatoid arthritis patients using subjective and objective methods. It is a cross-over study, so first half of patients will receive medicinal water, the other half will receive tap water treatment, and after 6 months treatments will be repeated, but patients will receive the other type of water.

Description

Several studies have shown that medicinal waters are highly effective in the treatment of many diseases. Existing clinical trials were unable to provide scientific evidence by using the highest international standards to justify the efficiency of thermal waters. Harkny medicinal water has been used for rheumatic, skin and locomotor diseases for more than 100 years. Its beneficial effects are indisputable. However, to introduce these effects, internationally high-level scientific methods and investigations are needed.

Psoriasis is among the most common dermatological diseases worldwide. Its significance is emphasized by adverse effects on quality of life, caused by chronic pain, physical and psychical disability due to psoriatic plaques. Former studies revealed an increased risk of inflammatory bowel disease, cardiovascular disease and certain types of cancer. Moreover, excessive oxidative stress can be responsible for the onset of psoriasis complications.

Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant morbidity, characterized by articular inflammation. Oxidative stress is a key marker for determining pathophysiology of patients with RA.

The pathophysiological link between these conditions is the presence of excessive oxidative stress.

Subjective methods will include questionnaires, objective markers of disease severity will include the measurement of biomarkers from blood samples.

Details

Condition	Psoriasis, Rheumatoid Arthritis, Rheumatoid Arthritis
Age	18years - 100years
Treatment	Harkány medicinal water, Tap water (placebo control)
Clinical Study Identifier	NCT04275206
Sponsor	University of Pecs
Last Modified on	19 February 2024

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	signed consent statement
	over 18 years of age
	lack of underlying renal disease (GFR >60 mL/min/1.73m2)
	lack of severe inflammation (WBC <20.000 G/l; CRP <50 mg/l; WE <40 mm/h)
	psoriasis vulgaris with skin lesions
	mild and inactive RA
Exclusion Criteria
	having received any kind of balneotherapy within 1 year before admission
	discontinuance of rehabilitation
	withdrawal of consent
	clinically significant difference in severity of the patient's condition on 1st or 2nd admission
	severe RA
	patients suffering from cancer
	patients suffering from inflammatory bowel disease
	patients underwent stroke within 1 year
	severe hypercholesterolemia
	severe diabetes
	patients with renal insufficiency
	patients receiving any kind biological therapy
	patients whose medication has changed during the study period or one month prior to the second treatment session

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The Anti-inflammatory Effects of Hark ny Medicinal Water